王国柱 肖斌 董博

    [摘要] 成人骨骼是一种经过不断重塑的多功能器官。骨骼的内稳态需要破骨细胞骨吸收和成骨细胞骨形成之间的平衡；如果这种平衡失调将导致骨质疏松症、硬化性骨病等各种骨骼疾病的发生。为了找到有效和安全的治疗方法来调节骨形成，必须阐明骨细胞分化和活动的分子机制。人类和小鼠的基因研究已经确立了Wnt信号作为刺激成骨细胞分化和活性的关键机制。本文就Wnt信号通路与骨形成相关机制以及治疗骨质疏松方法的相关研究进行综述。

    [关键词] 骨细胞；Wnt信号；骨质疏松；综述

    [中图分类号] R589 [文献标识码] A [文章编号] 1673-7210(2018)04(b)-0029-04

    Research progress of Wnt signaling pathway and osteoporosis treatment

    WANG Guozhu1 XIAO Bin1 DONG Bo2 YAO Jie2 CHEN Zhihui1 QIAN Bing1 Zhang Liping1

    1.Department of Orthopedics， the Second Affiliated Hospital of Shaanxi University of Chinese Medicine， Shaanxi Province， Xianyang 712000， China； 2.Department of Orthopedics， Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine， Shaanxi Province， Xianyang 712000， China

    [Abstract] Adult bone is a multifunctional organ that has been continuously reshaped. The homeostasis of bone requires the balance between osteoclast bone absorption and osteogenesis. If this imbalance can lead to osteoporosis， sclerosing osteopathy and other bone diseases. In order to find effective and safe treatment methods to regulate bone formation ......