李俊 翁育清 曾利恒

    [摘要] 目的 研究瘦素与肥胖成人哮喘Thl/Th2细胞因子及症状严重程度的相关性，进一步探讨肥胖成人哮喘的发病机制。 方法 选取2016年7～12月珠海市人民医院(以下简称“我院”)哮喘患者100例为研究对象，按照体重指数(BMI)将其分为肥胖哮喘组、非肥胖哮喘组各50例，选取同期我院健康体检者50例为对照组，并根据BMI分为肥胖组、正常体重对照组各25例。用酶联免疫吸附法(ELISA)测定血清瘦素、γ-干扰素(INF-γ)、白细胞介素-4(IL-4)及肺功能、哮喘控制测试(ACT)评分。分析瘦素与INF-γ、IL-4及肺功能、ACT评分之间的相关性。 结果 肥胖哮喘组瘦素、IFN-γ、IFN-γ/IL-4水平均高于其他组别(P 0.05)。 结论 肥胖哮喘组患者较其他组血清瘦素水平更高，与哮喘临床症状严重程度呈正相关，且有可能通过参与Th1型细胞因子所介导的气道高反应性。

    [关键词] 瘦素；肥胖；哮喘；细胞因子

    [中图分类号] R562.25 [文献标识码] A [文章编号] 1673-7210(2018)05(a)-0055-04

    [Abstract] Objective To observe the correlationship between serum leptin， Th1/Th2 cytokine and symptom severity in obese adult asthma patients， and investigate the pathogenesis of obese adult asthma. Methods From July to December 2016， 100 patients with asthma admitted to the Zhuhai People′s Hospital (“our hospital” for short) were selected as research objects， and they were divided into obese asthma group (50 cases) and non-obese asthma group (50 cases)by BMI. Fifty cases of healthy people at the same time in our hospital for physical examination were selected as control group， and were divided into obese group (25 cases) and non-obese control group (25 cases). Serum leptin ......