孙亚茹 赵海霞

    [摘要] 神经麻痹性角膜炎，也称神经营养性角膜炎，为三叉神经遭受外伤、手术、炎症或肿瘤等破坏时，失去神经支配的角膜敏感性下降，出现角膜营养障碍，对外界有害因素的防御能力减弱，因而角膜上皮干燥，易受机械性损伤，严重者可能会导致角膜溃疡、融解和穿孔。神经麻痹性角膜炎的治疗目的是促进角膜愈合和防止角膜损伤的进展，治疗方法包括物理疗法、药物疗法、手术治疗等。近几年来，新的治疗策略，如局部应用神经生长因子疗法，着重于改善角膜的神经支配以及支持角膜的生长和愈合。

    [关键词] 神经麻痹性角膜炎；物理治疗；药物治疗；睑缘缝合术；羊膜移植术；肉毒杆菌毒素A；神经生长因子

    [中图分类号] R772 [文献标识码] A [文章编号] 1673-7210(2018)05(c)-0022-04

    Advances in the treatment of neuroparalytic keratitis

    SUN Yaru ZHAO Haixia

    PRK Center， the Affiliated Hospital of Inner Mongolia Medical University， Inner Mongolia Autonomous Region， Hohhot 010050， China

    [Abstract] Neuroparalytic keratitis is also called as neurotrophic keratitis. When trigeminal nerve suffers from trauma， surgery， inflammation or tumor destruction， the sensitivity of cornea losing eneurosis will be decreased and the dystrophia will be occurred， the defense capability for the external harmful factors will be weakened， thus， the corneal epithelium will turn dry and be susceptible to mechanical damage. What's worse， it will probably result in corneal ulcer， fusion and perforation. The therapeutic aim of neuroparalytic keratitis is to promote corneal healing and prevent the progress of corneal damage. The treating methods include physical therapy ......