杨明 伏飞达 朱晓燕

    [摘要] 目的 探討突发性耳聋患者血清可溶性血管细胞黏附分子-1(sVCAM-1)的表达水平及临床意义。 方法 选择2016年1月～2017年6月南京市中西医结合医院收治的97例突发性耳聋患者作为病例组，并于同期随机选取60名健康体检者为对照组，采用酶联免疫吸附法测定两组血清sVCAM-1水平，并分析其与患者人口学资料的关系以及其对突发性耳聋的诊断价值。 结果 病例组患者血清sVCAM-1水平高于对照组，差异有统计学意义(P < 0.05)。≥45岁患者血清sVCAM-1水平高于<45岁者，听力损失严重患者血清sVCAM-1水平更高，全聋型患者血清sVCAM-1水平高于其他分型，有上呼吸道感染和心脑血管合并症患者血清sVCAM-1水平更高，差异均有统计学意义(P < 0.05)。sVCAM-1诊断突发性耳聋的ROC曲线下面积为0.904(95%CI：0.841～0.967)，灵敏度为76.5%，特异度为91.8%，此时sVCAM-1的最佳截断值为579.23 ng/mL。 结论 突发性耳聋患者血清sVCAM-1水平明显升高，其与年龄、听力下降程度、听力曲线、上呼吸道感染、心脑血管合并症密切相关，早期检测可有效预测突发性耳聋的发生。

    [关键词] 突发性耳聋；可溶性血管细胞黏附分子-1；临床意义

    [中图分类号] R764.43 [文献标识码] A [文章编号] 1673-7210(2018)05(c)-0119-04

    Changes and significance of serum sVCAM-1 level in patients with sudden deafness

    YANG Ming FU Feida ZHU Xiaoyan

    Department of ENT， Nanjing Integrated Traditional Chinese and Western Medicine Hospital， Jiangsu Province， Nanjing 210000， China

    [Abstract] Objective To explore the expression of serum soluble vascular cell adhesion molecule-1 (sVCAM-1) and its clinical significance. Methods A total of 97 patients with sudden deafness admitted to Nanjing Integrated Traditional Chinese and Western Medicine Hospital from January 2016 to June 2017 were selected as the case group ......