殷冬梅 阮祥燕 田玄玄 卢永军

    [摘要] 目的 探讨多囊卵巢综合征(PCOS)合并亚临床甲状腺功能减退(SCH)的患者胰岛素抵抗及脂代谢特征。 方法 选择 2015年9月～2016年10月在首都医科大学附属北京妇产医院内分泌门诊就诊的200例PCOS患者分为两组：41例合并亚临床甲减的研究组(SCH-PCOS组)和159例甲状腺功能正常的对照组(EU-PCOS组)；比较两组的临床特征、性激素水平、空腹胰岛素水平及血脂参数。 结果 SCH-PCOS组体重指数(BMI)、空腹胰岛素(FIN)及稳态模型评估的胰岛素抵抗指数(HOMA-IR)均大于EU-PCOS组，差异有统计学意义(P 0.05)。 结论 PCOS合并SCH比甲状腺功能正常的PCOS患者存在更严重的肥胖及胰岛素抵抗。

    [关键词] 多囊卵巢综合征；亚临床甲状腺功能减退；胰岛素抵抗；脂代谢

    [中图分类号] R711.75 [文献标识码] A [文章编号] 1673-7210(2018)06(b)-0068-04

    [Abstract] Objective To evaluate the characteristics of insulin resistance and lipid metabolism of PCOS patients with SCH. Methods A total of 200 patients with PCOS were recruited at the Department of Endocrinology， Beijing Obstetrics and Gynecology Hospital from September 2015 to October 2016. And they were divided into two groups： 41 cases of subclinical hypothyroidism (SCH-PCOS group) as study group and 159 cases of normal thyroid function (EU-PCOS group) as control group. The clinical features， sex hormone levels， fasting insulin levels and serum lipids between the groups were investigated. Results Body mass index (BMI) ......