鲁成 刘永明 陈启松

    [摘要] 目的 通過心脏彩色多普勒超声评价腹主动脉缩窄大鼠的心脏功能及潜阳合剂的干预作用。 方法 选取清洁级雄性Wistar大鼠40只，按随机数字表分为假手术组、模型组、中药组、培哚普利组，并行相应腹主动脉缩窄术或假手术，每组各10只。造模后8周开始药物干预，共干预12周。观察药物干预对外周血压、左心室肥厚以及左室功能的影响。 结果 造模20周后，模型组收缩压(SBP)明显升高(P < 0.05)，中药组和培哚普利组SBP低于模型组(P < 0.05)。模型组大鼠室间隔厚度(IVSd)显著增高(P < 0.05)，中药组和培哚普利IVSd均小于模型组(P < 0.05)。模型组二尖瓣舒张早期流速峰值(E峰)显著减小(P < 0.05)；中药组E峰大于模型组(P < 0.05)。模型组E/A比值显著降低(P < 0.05)，中药组E/A比值大于模型组(P < 0.05)。 结论 心脏彩色多普勒超声是评价腹主动脉缩窄大鼠心脏功能的有效方法。潜阳合剂可有效降低腹主动脉缩窄大鼠的外周血压，抑制左心室肥厚，并能改善左室舒张功能。

    [关键词] 潜阳合剂；腹主动脉缩窄；高血压；左心室肥厚；左室舒张功能；心脏彩色多普勒

    [中图分类号] R285.6 [文献标识码] A [文章编号] 1673-7210(2018)06(c)-0012-04

    [Abstract] Objective To evaluate cardiac function in rat models with abdominal aortic constriction and the therapeutic effect of Qianyang Decoction by means of color Doppler echocardiography. Methods Forty male Wistar rats， clean grade， were divided into four groups by random number table， including sham group， control group， TCM group and Perindopril group， with 10 rats in each group. All rats were undergone the abdominal aortic constriction surgery， except the rats in the sham group. Drug intervention was initiated 8 weeks after the models were made ......