刘亚东 邢延芳

    [摘要] 传统反映肾脏急性损伤(AKI)的标志物在出现异常改变时，肾脏往往已发生微观形态学和组织学改变，从而严重影响患者预后。本文从生物学特点、分布表达、损伤机制、检测时机、优势及不足等方面对新型生物标志物人中性粒细胞明胶酶相关脂质运载蛋白、肾损伤分子1、胱蛋白酶抑制物C、白细胞介素18、N-乙酰-β-D氨基葡萄糖苷酶、人肝型脂肪酸结合蛋白、胰岛素样生长因子结合蛋白-7进行综述，以期为AKI早期诊断、发生发展及预测预后等方面提供临床依据。

    [关键词] 人中性粒细胞明胶酶相关脂质运载蛋白；肾损伤分子1；胱蛋白酶抑制物C；白细胞介素18；N-乙酰-β-D氨基葡萄糖苷酶；人肝型脂肪酸结合蛋白；胰岛素样生长因子结合蛋白-7

    [中图分类号] R692 [文献标识码] A [文章编号] 1673-7210(2018)06(c)-0032-04

    [Abstract] When the markers of acute kidney injury (AKI) are abnormal， the kidney often has micromorphology and histological changes， which seriously affect the prognosis of the patients. In this paper， the biological markers of human neutrophil gelatinase-associated lipocalin， kidney injury molecule 1， cystine inhibitor C， interleukin-18， N-acetyl-beta-D glucosaminidase， liver fatty acid binding protein and insulin like growth factor binding protein-7 are reviewed in order to provide a clinical basis for the early diagnosis， development and prognosis of AKI.

    [Key words] Gelatinase-associated lipocalin； Kidney injury molecule 1； Cystine inhibitor C； Interleukin-18； N-acetyl-beta-D glucosaminidase； Liver fatty acid binding protein； Insulin like growth factor binding protein-7 ......