黄琳惠 黄奕江

    [摘要] 目的 評估螺旋CT联合血清癌胚抗原(CEA)、解整合素-金属蛋白酶8(ADAM8)在老年肺癌临床诊断中的应用价值。 方法 选取2016年1～12月海南省人民医院(以下简称“我院”)收治的72例老年肺癌患者作为研究组，另外选择同时期在我院就诊的肺部良性疾病患者40例及健康体检者40名作为对照，所有研究人员均行CT扫描并对血清中CEA、ADAM8进行检测，以组织病理结果作为金标准，判断各指标单独及联合检测对肺癌的诊断价值。 结果 肺癌组患者血清中CEA、ADAM8的含量明显高于肺部良性病变组和健康对照组(P < 0.05)；其中肺癌Ⅲ/Ⅳ期肺癌患者血清各指标水平明显高于Ⅰ/Ⅱ期患者(P < 0.05)。CT、CEA、ADAM8单项检测的敏感度分别为68.06%、48.61%、70.83%，特异度分别为90.00%、75.00%、86.25%，准确度为79.61%、62.50%、78.95%，三指标联合后的敏感度、特异度及准确度分别为83.33%、93.75%、88.82%，均高于单项检测。 结论 CEA对肺癌患者的检出率较低，且易出现假阳性，但与CT和ADAM8联合后能够明显提高肺癌检测的准确性。

    [关键词] 肺癌；螺旋CT；癌胚抗原；解整合素-金属蛋白酶8；诊断学

    [中图分类号] R734.2 [文献标识码] A [文章编号] 1673-7210(2018)07(a)-0147-04

    Value of CT combined with serum CEA and ADAM8 in the diagnosis of lung cancer in elderly patients

    HUANG Linhui HUANG Yijiang

    Department of Respiratory and Critical Medical， Hainan Provincial People′s Hospital， Hainan Province， Haikou 570311， China

    [Abstract] Objective To evaluate the value of spiral CT combined with serum carcinoembryonic antigen (CEA) and a disintegrin and metalloprotease 8 (ADAM8) in the clinical diagnosis of elderly patients with lung cancer. Methods A total of 72 elderly patients with lung cancer admitted in Hainan Provincial People′s Hospital (for short “our hospital”) from January to December in 2016 were selected as the study group ......