程怡安 谭诗云 李明

    [摘要] 炎症性肠病(IBD)是一类累及肠道的慢性炎症性疾病，现有的研究认为环境、遗传、免疫、感染等多种因素可能参与其发病机制。幽门螺杆菌(H.pylori)是人类最普遍的病原体之一，与多种胃内外疾病有关。近些年，较多的数据显示两者之间存在一定的负相关性，研究发现这种关联可能与H.pylori的免疫调节特性或其他混杂因素如抗生素、柳氮磺胺嘧啶等药物及环境因素有关。此外，有文献报道了H.pylori根除之后新发IBD的病例，并提出根除H.pylori可能通过影响Th1和Th2免疫应答之间的平衡而触发克罗恩病。本文针对H.pylori与IBD的关系、机制以及H.pylori根治后IBD的发展作一综述。

    [关键词] 幽门螺杆菌；炎症性肠病；相关性；免疫

    [中图分类号] R574 [文献标识码] A [文章编号] 1673-7210(2018)07(c)-0027-04

    The research progress of association between Helicobacter pylori and inflammatory bowel disease

    CHENG Yi′an TAN Shiyun LI Ming

    Department of Gastroenterology， Renmin Hospital of Wuhan University， Hubei Province， Wuhan 430060， China

    [Abstract] Inflammatory bowel disease (IBD) is a chronic inflammatory disease affecting intestinal tract. Existing researches suggest that environment， genetics， immunity and infection may be involved in its pathogenesis. Helicobacter pylori (H.pylori) is a common human pathogen， which is associated with a variety of gastric and extra-gastric diseases. In recent years， a lot of data show a negative correlation between them ......