方玲 张琪 魏恩韬 贾紫珮

    [摘要] 胰岛素生理作用的发挥与其信号转导的正常运行密切相关，转导途径的任何一个环节受损均可导致胰岛素抵抗(IR)，PI3K/Akt是胰岛素信号传导的经典途径，也是中医药预防治疗IR相关疾病的重要靶点之一。本文概述了PI3K/Akt信号通路及其与IR的关系，并以此为出发点，将近年来应用于实验研究的中药单体及复方进行简要综述，以期为研究者更深入地探讨中医药防治IR的机制提供参考。

    [关键词] PI3K/Akt信号通路；胰岛素抵抗；中医药；研究进展

    [中图分类号] R285.5 [文献标识码] A [文章编号] 1673-7210(2018)08(b)-0026-04

    [Abstract] The physiological function of insulin is closely related to the normal operation of insulin signal transduction. Impaired in any part of the transduction pathway can lead to insulin resistance(IR). PI3K/Akt signaling is the classical pathway of insulin signaling， and it is also one of the important targets for the prevention and treatment of IR-related diseases in Chinese medicine. This article summarizes the PI3K/Akt signal pathway and its relationship with IR， and as a starting point， a brief review of traditional Chinese medicine monomers and compounds used in experimental research in recent years， in order to provide researchers with more in-depth study of Chinese medicine prevention and treatment of IR.

    [Key words] PI3K/Akt signaling pathway； Insulin resistance； Traditional Chinese medicine； Research progress ......