姜茜 黄建华 郑军 刘英杰

    [摘要] 目的 探讨加味知柏地黄丸合阿仑膦酸钠维D3片对绝经后骨质疏松症肝肾不足证患者骨密度、血清雌二醇和免疫功能的影响。 方法 选取2014年10月～2016年4月在瑞安市中医院就诊的绝经后骨质疏松症肝肾不足证患者200例，根据随机数字表法将其分为对照组和治疗组，各100例。对照组采用阿仑膦酸钠维D3片联合骨康胶囊治疗，治疗组给予加味知柏地黄丸合阿仑膦酸钠维D3片治疗。比较两组骨密度、血清雌二醇水平及免疫功能。 结果 与治疗前比较，两组腰1～腰4(L1～L4)、左股骨颈(FN)骨密度和血清雌二醇水平、IgG、IgM水平均上升，差异有统计学意义(P 0.05)。 结论 加味知柏地黄丸合阿仑膦酸钠维D3片治疗可有效改善绝经后骨质疏松症肝肾不足证患者免疫功能，调节激素水平，促进骨密度增加。

    [关键词] 绝经后骨质疏松；加味知柏地黄丸；阿仑膦酸钠维D3片；骨密度；雌二醇；免疫功能

    [中图分类号] R274.91 [文献标识码] A [文章编号] 1673-7210(2018)08(b)-0117-04

    [Abstract] Objective To investigate the effect of Modified Zhibai Dihuang Pills combined with Alendronate Sodium and Vitamin D3 Tablets on bone mineral density， estradiol and immune function in postmenopausal osteoporosis (PMO) patients with deficiency of liver and kidney. Methods Two hundred PMO patients with deficiency of liver and kidney in Rui′an Hospital of Traditional Chinese Medicine from October 2014 to April 2016 were selected， and they were divided into control group and treatment group by random number table， with 100 cases in each group. The control group was given Alendronate Sodium and Vitamin D3 Tablets combined with Gukang Capsules ......