李丽娟 王庆高 何亚州

    [摘要] 动脉粥样硬化(AS)引发的心脑血管疾病是造成死亡的主要原因之一，而AS是多因素、多机制协同作用的结果，内皮细胞功能障碍、血管平滑肌细胞增殖迁移、脂质代谢紊乱、炎性反应、细胞自噬等参与其中。因AS发病的复杂性，仍需从不同的角度完善对其发病机制的认识。近年来长链非编码RNA(lncRNA)被发现也参与基因的表达调控，作为肿瘤的生物标志物和治疗靶点已被广泛研究和应用，但在AS的研究尚处初始阶段。本文综述了lncRNA参与AS主要病变过程中的研究进展，以期为防治AS提供新思路。

    [关键词] 动脉粥样硬化；长链非编码RNA；病变；研究进展

    [中图分类号] R543.3 [文献标识码] A [文章编号] 1673-7210(2018)08(c)-0022-04

    [Abstract] The cardiovascular and cerebrovascular diseases caused by atherosclerosis (AS) is one of the main causes of death. AS is the result of synergistic effect of multiple factors and multiple mechanisms. The endothelial dysfunction， proliferation and migration of vascular smooth muscle cell， lipid metabolism disorders， inflammatory response and autophagy are involved in AS. Because of the complexity of its pathogenesis， it still needs to improve the understanding of its pathogenesis from different perspectives. In recent years， long non-coding RNA is found involving in regulating gene expression， as biomarkers and therapeutic targets for tumors， it has been widely studied and applied. However， lncRNA in atherosclerosis is still in early stage. This article reviews the research progress of lncRNA in the pathogenesis of AS ......