薛白 高汝钦 刘丽

    [摘要] 目的 探讨高尿酸血症对糖尿病发病的影响，为预防糖尿病提供科学依据。 方法 本研究采用队列研究的方法，选择参加2009年7月基线调查并且在2012年12月被随访到的有完整尿酸及糖尿病资料的35～74岁青岛市常驻居民为研究对象，共2177人纳入本次研究。利用非条件Logistic回归计算优势比。用Bruzzi等定义的公式估计人群归因危险度。 结果 同时控制混杂因素后，高尿酸血症史的OR值为1.497，多因素人群归因危险度为6.71%。 结论 高尿酸血症史是糖尿病的独立危险因素，青岛市糖尿病的发生部分归因于高尿酸血症史。

    [关键词] 队列研究；糖尿病；高尿酸血症；人群归因危险度

    [中图分类号] R155.5 [文献标识码] A [文章编号] 1673-7210(2018)08(c)-0042-04

    [Abstract] Objective To investigate the effect of hyperuricemia on diabetes attack， and provide scientific basis for the work of prevention. Methods Cohort study was conducted in this study. Subjects were selected to participate in the baseline survey in July 2009. A three-year follow-up was conducted for those who met the conditions. The follow-up ended in December 2012. Eventually 2177 people aged 35 to 74 that had lived in Qingdao for years were included in the study. Non-conditional Logistic regression analysis was used to calculate the advantage ratio. The population attributable risk was estimated by using the formula defined by Bruzzi. Results After controlling for confounding factors ......