张浩然 乔旭旭 毕明宏

    [摘要] 自噬与肿瘤细胞的恶性转化和分化有关。哺乳动物雷帕霉素靶蛋白(mTOR)通路和细胞自噬关系密切，其可通过调控细胞自噬而在肿瘤的发生和发展中发挥重要的作用。目前mTOR抑制剂(靶向抑制信号通路)的开发已成为抗肿瘤研究的重要领域，这将会是潜在的肿瘤治疗方法。本文就自噬通路中mTOR信号通路与肿瘤关系以及mTOR抑制剂的研究进展进行综述，希望能为肿瘤的研究及靶向药物的研制提供信息。

    [关键词] 自噬；肿瘤；哺乳动物雷帕霉素靶蛋白；治疗；研究进展

    [中图分类号] R730.2 [文献标识码] A [文章编号] 1673-7210(2018)09(a)-0032-04

    [Abstract] Autophagy capacity may correlate with malignant transformation and differentiation of cancer cells. The mammalian target of rapamycin (mTOR) has close relationship with autophagy， which can play an important role through regulating the autophagic activity on cancer genesis and progression. So far mTOR inhibitors (inhibiting targets of signaling pathways) have potential in the future for cancer therapy， the development of mTOR inhibitors represents an important field in anticancer research. This article summarizes the relationship between mTOR signaling pathway and tumor in autophagy pathways， and the current status of the development of mTOR inhibitors， it hopes to provide information for studies on cancer research and targets for tumor therapy.

    [Key words] Autophagy； Tumor； Mammalian target of rapamycin； Therapy； Research progress ......