李翠霞 苏秀兰

    [摘要] 斑马鱼因具有体外受精、胚胎透明及繁殖能力强等小模式生物独特优势，近十年已经被广泛作为人类相关性疾病研究模型。目前针对斑马鱼的基因操作技术已相当成熟，靶向性地诱导或敲除体内某些基因，改变其表达水平，可以很容易地在斑马鱼上复制人类的一些肿瘤性疾病状态，因此适合建立斑马鱼各种类型肿瘤模型，并进行相关机制研究。本文就斑马鱼作为肿瘤模型的优势及斑马鱼各种类型肿瘤模型的研究做一综述，分析斑马鱼作为模式动物在抗肿瘤药物的研究中的应用价值。

    [关键词] 斑马鱼；肿瘤模型；药物研究；应用价值

    [中图分类号] R73-35 [文献标识码] A [文章编号] 1673-7210(2018)09(b)-0022-04

    [Abstract] Zebrafish have been successfully widely used as a research models for human-related diseases in the past decade due to their unique advantages in small-scale Organisms such as in vitro fertilization， embryo transparency and strong reproductive ability. At present， the gene manipulation technology for zebrafish has been quite mature， Targeting to induce or knock out certain genes in the body and change its expression level， it is easy to replicate some human tumor diseases on zebrafish， so various types of zebrafish tumor models can be established， and are suitable for conducfing reserch on related mechanisms. This article reviews the advantages of zebrafish as a tumor model and the research of various types of zebrafish tumor models， and the application value of zebrafish as a model animal in the study of anti-tumor drugs was analyzed. ......