梁颖 黄汉辉 赖天幸 邹端 林彩燕 陈晞明 严鹏科

    [摘要] 目的 探讨紫杉醇药物涂层球囊治疗冠脉支架内再狭窄的临床效果。 方法 选择2015年1月～2016年12月广州医科大学附属第三医院收治的87例冠脉支架内再狭窄患者，按随机数字表法将其分为对照组(43例)和治疗组(44例)。对照组给予药物洗脱支架治疗，治疗组给予紫杉醇药物涂层球囊治疗。观察并比较两组术后1、6、12个月的心血管不良事件发生率及两组术后12个月时的支架内再狭窄发生率。 结果 治疗组术后心血管不良事件总发生率(6.82%)及术后12个月时支架内再狭窄发生率(6.82%)均明显低于对照组(23.26%、27.91%)，差异有统计学意义(χ2=4.623，P = 0.032；χ2=6.778，P = 0.009)。 结论 紫杉醇药物涂层球囊治疗冠脉支架内再狭窄的临床效果显著，能够明显减少心血管不良事件的发生，可避免再次置入支架，值得临床推广应用。

    [关键词] 冠脉支架内再狭窄；紫杉醇；药物涂层球囊；药物洗脱支架

    [中图分类号] R654.2 [文献标識码] A [文章编号] 1673-7210(2018)09(b)-0043-03

    [Abstract] Objective To explore the clinical efficacy of drug-coated balloon with Paclitaxel for treatment of coronary in-stent restenosis. Methods Eighty-seven patients with coronary in-stent restenosis admitted to the Third Affiliated Hospital of Guangzhou Medical University from January 2015 to December 2016 was divided into control group (43 cases) and treatment group (44 cases) by random number table method. Control group was treated with drug-eluting stent， while treatment group was treated with drug-coated balloon with Paclitaxel. The rate of cardiovascular adverse events after operation for 1 ......