丙戊酸钠联合左乙拉西坦治疗脑卒中后癫痫的临床探讨
李俊毅[摘要] 目的 探討丙戊酸钠联合左乙拉西坦治疗脑卒中后癫痫的临床效果。 方法 回顾性分析陕西省铜川市人民医院2014年2月~2017年3月收治的脑卒中后癫痫患者90例的临床资料,依据治疗方式的不同将其分为对照组和观察组,每组45例。对照组给予丙戊酸钠,观察组给予丙戊酸钠联合左乙拉西坦。观察并比较两组患者治疗前后癫痫发作次数、发作持续时间、痫样放电、累及导联数和神经元特异性烯醇化酶(NSE)、肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)水平,以及临床疗效、不良反应情况。 结果 两组患者治疗前癫痫发作次数、发作持续时间、痫样放电、累及导联数和NSE、TNF-α、IL-2、IL-6水平比较差异无统计学意义(P > 0.05)。治疗后两组患者癫痫发作次数、发作持续时间、痫样放电、累及导联数和NSE、TNF-α、IL-2、IL-6水平均明显低于治疗前(P 0.05)。结论 丙戊酸钠联合左乙拉西坦治疗脑卒中后癫痫患者可以改善临床症状,提高临床效果,值得临床推广应用。
[关键词] 丙戊酸钠;左乙拉西坦;脑卒中;癫痫
[中图分类号] R742.1 [文献标识码] A [文章编号] 1673-7210(2018)09(b)-0109-04
[Abstract] Objective To explore the clinical effect of Sodium Valproate combined with Levetiracetam in the treatment of epilepsy after stroke. Methods The clinical data of 90 cases of patients with epilepsy after stroke admitted to Tongchuan People's Hospital from February 2014 to March 2017 was analyzed retrospectively and the patients were divided into control group and observation group by different treatments, with 45 cases in each group. The control group was treated with Sodium Valproate, the observation group was treated with Sodium Valproate combined with Levetiracetam. The seizures number ......
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