李妍 孙淼 李慕白

    [摘要] 代谢综合征和肥胖在儿童及青春期人群中发生率逐步增加。因为代谢综合征的定义至今尚未统一，所以对于儿童及青春期代谢综合征的诊断尚存在争议。虽然其发病机制仍不明确，但胰岛素抵抗及其继发的炎症表现在其发病中起到重要的作用。代谢综合征的主要临床表现是超重和肥胖，以及葡萄糖代谢异常、脂代谢异常和高血压。脂肪肝、多囊卵巢综合征和促炎症状态等与代谢综合征密切相关。对于存在高危因素的儿童及青少年应定期进行规范的代谢综合征筛查。

    [关键词] 代谢综合征；儿童；青春期；诊断；筛查

    [中图分类号] R4 [文献标识码] A [文章编号] 1673-7210(2018)09(c)-0034-04

    [Abstract] The incidence of metabolic syndrome and obesity in children and adolescents has increased gradually. As the definition of metabolic syndrome has not been unified， the diagnosis of children and adolescents metabolic syndrome is still controversial. Although the pathogenesis is still unclear， insulin resistance and subsequent inflammation play an important role in the pathogenesis. The main clinical manifestations of metabolic syndrome are overweight and obesity， abnormal glucose metabolism， dyslipidemia， and hypertension. Fatty liver， polycystic ovary syndrome and pro-inflammatory state have close correlation with metabolic syndrome. Regular screening of metabolic syndrome should be carried out for children and adolescents with high risk factors.

    [Key words] Metabolic syndrome； Children； Adolescent； Diagnosis； Screening ......