张宏 王旭昀 郑伟康

    [摘要] 膝骨关节炎是中老人常见的慢性膝关节退化性疾病，晚期关节可出现屈伸受限、蹲起困难，严重时不能行走。膝骨关节炎临床治疗中药物治疗占有重要的地位，但合理用药并没有受到重视。药物治疗包括口服药物和外用药物。大多数患者长期服用消炎止痛药物，并对其治疗的适应症及副作用认知不足；部分患者对外用药物的应用了解不够。本文主要对治疗膝骨关节炎的内服药物，如镇痛药、软骨保护药物；关节腔注射药物，如透明质酸、玻璃酸钠、医用几丁糖、激素类药物、自体富血小板血浆、臭氧等，以及外用药物进行归纳分析，以便更好的指导临床用药，提高膝骨关节炎的治疗效果。

    [关键词] 膝骨关节炎；口服药物；外用药物；药物治疗

    [中圖分类号] R246.9 [文献标识码] A [文章编号] 1673-7210(2018)09(c)-0038-04

    [Abstract] Knee osteoarthritis is a common chronic degenerative disease of knee joint. In the advanced stage， the joint may appear to bend and stretch limitation， crouch difficult， and some people even can′t walk when it′s serious. Drug treatment plays an important role in the clinical treatment of knee osteoarthritis， but rational drug use has not received much attention. Drug treatment include oral and topical drugs. Most patients take anti-inflammatory and analgesic drugs for a long time， and they are not aware of the indications and side effects of their treatment； some patients do not know enough about the application of external drugs. Oral drugs include analgesics， cartilage protection drugs； intra-articular injection of drugs include hyaluronic acid ......