张妍 苏晓蕾 赵睿

    [摘要] 目的 探討替加环素治疗多重耐药菌所致重症肺炎的效果及对氧代谢状态的影响。 方法 选择2016年10月～2017年11月于大连市中心医院确诊的92例多重耐药菌所致重症肺炎患者，依据治疗方式的不同将其分为对照组和研究组，每组各46例。对照组给予头孢哌酮舒巴坦静滴治疗，研究组在对照组治疗的基础上给予替加环素静脉滴注。两组均治疗3 d。观察比较两组治疗后的效果，检测两组患者治疗前1 d和治疗后3 d的氧代谢状态(氧供与氧耗状态)，比较两组治疗中的不良反应发生率。 结果 治疗后，研究组的疗效优于对照组，差异有统计学意义(P 0.05)。 结论 替加环素治疗多重耐药菌所致重症肺炎患者的效果较好，有助于改善患者的氧代谢状态，且未明显增加不良反应，值得推广应用。

    [关键词] 替加环素；头孢哌酮舒巴坦；多重耐药菌；重症肺炎；氧代谢状态

    [中图分类号] R978.14 [文献标识码] A [文章编号] 1673-7210(2018)09(c)-0106-04

    [Abstract] Objective To investigate the effect of Tigecycline in the treatment of severe pneumonia caused by multidrug resistant bacteria and its influence on oxygen metabolism state. Methods From October 2016 to November 2017， 92 patients diagnosed as severe pneumonia caused by multidrug resistant bacteria in Dalian Municipal Central Hospital were selected and divided into control group and study group according to the different treatment methods， with 46 cases in each group. The control group was treated with Cefoperazone-Sulbactam by intravenous drip， the study group was treated with Tigecycline by intravenous drip on the basis of treatment of control group. The treatment of two groups lasted for 3 d. The curative effects of the two groups were observed and compared after treatment ......