冯霞 余利军 邓国祥

    [摘要] 目的 探讨注射用奥美拉唑钠与20种临床常用中药注射剂配伍后的稳定性，为临床合理使用奥美拉唑钠提供依据。 方法 在解放军兰州总医院静脉用药集中调配中心(PIVAS)水平层流台按照医嘱配制好注射用奥美拉唑钠成品输液，分别与20种中药注射剂成品输液等比例混合，在0～6 h内观察混合液的外观性状，检测其pH和不溶性微粒数。 结果 奥美拉唑钠与银杏达莫、银杏叶提取物、舒肝宁、红花黄色素、灯盏花素、丹参川芎嗪、丹参多酚酸盐配伍后颜色显著改变；奥美拉唑钠与20种中药注射剂配伍后pH显著降低，不溶性微粒含量显著增加(P < 0.05)。 结论 临床使用奥美拉唑钠时应该避免与中药注射剂配伍使用，序贯使用需要冲洗输液管路。

    [关键词] 注射用奥美拉唑钠；中药注射剂；配伍；稳定性

    [中图分类号] R969 [文献标识码] A [文章编号] 1673-7210(2018)09(c)-0154-04

    [Abstract] Objective To study the stability of Omeprazole Sodium for Injection combined with 20 commonly used TCM injections in clinic， in order to provide basis for reasonable clinical use of Omeprazole Sodium. Methods Omeprazole Sodium for Injection was prepared at horizontal laminar flow in pharmacy intravenous admixture services (PIVAS) of Lanzhou General Hospital of PLA according to the doctor′s advice， and mixed with 20 TCM Injections at equal proportion. The appearance of the mixture was observed and the pH value and insoluble particles were detected in 0-6 h. Results The color changes appeared when Omeprazole Sodium mixed with Ginkgo Leaf Extract and Dipyridamole Injection ......