刘宇 郑蕊 王凤云 唐旭东 马祥雪 石啸双 孙巧红 金静

    [摘要] 目的 药效学结合有效成分含量优选肠安Ⅰ号方的提取工艺，并探究复方中有效成分含量与药效学指标间的相关性。 方法 通过小鼠止泻及镇痛试验确定最佳提取工艺路线，并通过SPSS 17.0软件对肠安Ⅰ号方治疗肠易激综合征的有效成分与药效学指标进行Pearson相关系数分析。 结果 肠安Ⅰ号方最佳提取工艺路线为全方水提，其有效成分芍药苷含量与镇痛率呈正相关(P 0.05)。 结论 采用量效融合法评价优选最佳提取工艺是科学合理的，为中药提取工艺的优化提供了一种新的思路，同时也为肠安Ⅰ号方的临床应用提供了可靠的实验依据。

    [关键词] 肠安Ⅰ号方；肠易激综合征；提取工艺；量效

    [中图分类号] R574.4 [文献标识码] A [文章编号] 1673-7210(2018)10(a)-0021-04

    Optimized extraction technology of Chang′an No.Ⅰ based on dose-effect fusion evaluation method

    LIU Yu1 ZHENG Rui1 WANG Fengyun2 TANG Xudong2 MA Xiangxue2 SHI Xiaoshuang2 SUN Qiaohong1 JIN Jing1

    1.Manufacturing Laboratory of Chinese Medicine， Xiyuan Hospital， China Academy of Chinese Medical Sciences， Beijing 100091， China； 2.Department of Spleen and Stomach Diseases， Xiyuan Hospital， China Academy of Chinese Medical Sciences， Beijing 100091， China

    [Abstract] Objective To optimize the extraction technology of Chang′an No.Ⅰ by pharmacodynamics combined with active ingredient contents， and to explore the correlation between active ingredient contents and pharmacodynamics indicators. Methods The antidiarrheal and analgesic tests were used to optimize the best extraction process. SPSS 17.0 software was used to analyze the Pearson correlation between the active ingredients of Chang′an No.Ⅰ in the treatment of irritable bowel syndrome and pharmacodynamics indicators. Results The best optimal extraction process of Chang′an No.Ⅰ was water extract. There was a positive correlation between paeoniflorin content and analgesic rate (P < 0.01) ......