徐丽英 钟萍 曹烨民

    [摘要] 脂联素是脂肪细胞分泌细胞因子，它可与受体结合，具有改善糖、脂代谢，增加胰岛素敏感性，保护血管内皮细胞的功能。心血管系统中，其具有抗炎、抑制动脉粥样硬化等作用。脂联素与胰岛素抵抗、肥胖及2型糖尿病发病风险相关，并可降低高血压的发病风险。脂联素在不同种族、年龄、性别的群体中的表达有差异。脂联素具有保护心血管的作用，可预示糖尿病大血管严重程度。本文就脂联素的受体、信号传导，脂联素与血管危险因素及糖尿病大血管、微血管病变的相关性进行了综述。

    [关键词] 脂联素；炎症；动脉粥样硬化；糖尿病

    [中图分类号] R587.1 [文献标识码] A [文章编号] 1673-7210(2018)10(a)-0029-04

    Relationship between adiponectin and diabetes mellitus and its complications

    XU Liying1 ZHONG Ping2 CAO Yemin1

    1.Department of Vasculitis， Shanghai TCM-Integrated of Shanghai University of Chinese Medicine， Shanghai 200082， China； 2.Department of Encephalopathy， Shanghai TCM-Integrated of Shanghai University of Chinese Medicine， Shanghai 20082， China

    [Abstract] Adiponectin is a cytokine secreted by dipocytes. It binds to receptors and has functions to improve sugar and lipid metabolism， increase insulin sensitivity， and protect vascular endothelial cells. It has anti-inflammatory and anti atherogenic effects in cardiovascular system. Adiponectin is associated with insulin resistance， obesity， and the risk of developing type 2 diabetes ......