李洵 艾文兵

    [摘要] 胶质瘤是最常见的成人原发性颅内恶性肿瘤。当前治疗手段包括手术、放疗和口服化疗药物替莫唑胺。这些治疗手段均有一定的治愈率，但仍有复发的可能，主要是由于肿瘤细胞在肿瘤治疗过程中仍能存活并能够重建肿瘤。因此，明确调节肿瘤细胞这一活动的分子机制对于肿瘤的治疗至关重要。胶质瘤干细胞(GSC)对常规放化疗耐受可能是胶质瘤易复发的原因之一。GSC所处的肿瘤微环境与GSC的发生发展有关，这也为胶质瘤的治疗提供了一个全新思路。本文重点综述了GSC相关肿瘤微环境的研究进展及通过靶向微环境治疗胶质瘤。

    [关键词] 微环境；胶质瘤；胶质瘤干细胞；靶向治疗

    [中图分类号] R739.41 [文献标识码] A [文章编号] 1673-7210(2018)10(a)-0033-04

    Research on glioma microenvironment

    LI Xun1 AI Wenbing2

    1.Medical College of China Three Gorges University， Hubei Province， Yichang 443000， China； 2.Yiling Hospital of Yichang City， Hubei Province， Yichang 443000， China

    [Abstract] The glioma is the most common primary intracranial malignancy in adults. Current treatments include surgery， radiotherapy， and oral chemotherapy drug temozolomide. These treatments have a certain cure rate， but there is still the possibility of recurrence. The main reason is that tumor cells can survive and rebuild tumors during the treatment. Therefore， it is essential for the treatment of tumors to know the molecular mechanism that regulates the activity of tumor cells. Glioma stem cells (GSC) tolerance to conventional radiotherapy and chemotherapy may be one of the causes of glioma recurrence. The tumor microenvironment in which GSC located is related to the development of GSC ......