罗慧 杨光博 符锋 孙洪涛 令狐海瑞

    [摘要] 轻型颅脑创伤(mTBI)可导致大脑结构或功能改变，表现为局灶性神经、认知或行为功能障碍。目前mTBI的诊断标准是非常有限的、可变的，且多基于主观的自我报告，因此限制了临床医生的准确诊断、治疗方案制订和预后评估等。高级神经影像学技术的发展，使客观化评估mTBI成为可能。本文将综述几项颇有前景的成像技术及其应用，以了解mTBI后的大脑异常改变。这些成像方式包括理解大脑结构和组织结构、监测局部血流、评估微出血、测量脑功能及代谢情况的技术。

    [关键词] 轻型颅脑创伤；神经影像学；诊断；大脑结构

    [中图分类号] R651.1 [文献标识码] A [文章编号] 1673-7210(2018)10(c)-0019-05

    [Abstract] Mild traumatic brain injury (mTBI) can lead to changes in brain structure or function， manifested as focal neurological， cognitive or behavioral dysfunction. At present， the diagnostic criteria of mTBI is very limited， variable， and mostly based on subjective self-reporting， which limits the clinician's accurate diagnosis， treatment plan formulation， and prognostic evaluation. The development of advanced neuroimaging has made it possible to objectively evaluate mTBI. This article reviews several promising imaging techniques and their applications to understand abnormal brain changes after mTBI. These imaging modalities include understanding of brain structure and tissue structure， monitoring of local blood flow ......