周晶莹 周宁 张祎雯

    [摘要] 绝经后骨质疏松症的发病机制与骨保护素(OPG)/核因子-κB受体活化因子(RANK)/核因子-κB受体活化因子配体(RANKL)系统功能紊乱密切相关。未成熟的成骨细胞分泌RANKL，RANK与其结合，刺激破骨细胞分化成熟并抑制其凋亡，从而促进骨吸收；成熟的成骨细胞分泌OPG，与RANK竞争性结合RANKL，从而抑制破骨细胞分化成熟并诱导其凋亡，降低骨吸收。中药及针刺尤其是补肾或补肾健脾的中药及穴位针刺可有效调节OPG/RANK/RANKL系统，这可能是中药及针刺防治绝经后骨质疏松症的作用机制之一。

    [关键词] 绝经后骨质疏松症；OPG/RANK/RANKL；中药；针刺

    [中图分类号] R681 [文献标识码] A [文章编号] 1673-7210(2018)11(c)-0025-04

    General experiment study about regulating effect on OPG/RANK/RANKL system of ovariectomized osteoporosis rats by traditional Chinese medicine and acupuncture

    ZHOU Jingying1 ZHOU Ning2 ZHANG Yiweng3 YANG Hongguang4 ZHAO Yingxia3

    1.Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine， Shanghai 200120， China； 2.College of Acumox and Tuina， Shanghai University of Traditional Chinese Medicine， Shanghai 201203， China； 3.College of Basic Medicine， Shanghai University of Traditional Chinese Medicine， Shanghai 201203， China； 4.Clinical Medical School of Longhua， Shanghai University of Traditional Chines Medicine， Shanghai 200032， China

    [Abstract] The pathogenesis of postmenopausal osteoporosis is closely related to the dysfunction of osteoprotegerin (OPG)/ receptor activator of nuclear factor κB (RANK)/ receptor activator of nuclear factor κB ligand (RANKL) system. Immature osteoblast secretes RANKL ......