刘尧 熊苗苗 陈雅洁

    [摘要] 维生素C(VitC)又称抗坏血酸，是人体内的高效抗氧化剂，在机体多种生物合成过程中发挥着重要作用。维生素C缺乏普遍存在于各种患者中，如创伤、感染以及癌症患者。最近许多临床研究表明，静脉应用高剂量VitC能够预防骨折后复杂区域性疼痛综合征的发生，也可以缓解带状疱疹急性期疼痛，并且能够有效地降低带状疱疹后神经痛的发生率。此外，高剂量VitC可以减轻晚期癌症患者的疼痛，延长患者生存时间。众多专家已提出几种关于VitC缓解疼痛的机制，但目前仍存在争议。总而言之，VitC在减轻急、慢性疼痛中表现出了安全且有效的作用。

    [关键词] 维生素C；骨骼相关疼痛；帶状疱疹神经痛；癌痛；术后疼痛

    [中图分类号] R977 [文献标识码] A [文章编号] 1673-7210(2018)11(c)-0036-04

    [Abstract] Vitamin C (VitC)， also known as ascorbic acid， is a highly effective antioxidant in the human body and plays an important role in many biosynthetic processes. VitC deficiency is highly prevalent in a variety of patients， such as patients with trauma， infection， and cancer. Many recent clinical studies have shown that intravenous high-dose VitC can prevent the occurrence of complex regional pain syndrome after fracture. It can also relieve the herpes zoster pain and reduce the incidence of postherpetic neuralgia. In addition， the high-dose VitC can reduce pain in patients with advanced cancer and extend their survival time. Many experts have proposed several mechanisms for relieving pain in VitC ......