刘传铃 王佳贺

    [摘要] 铜绿假单胞菌已成为临床上最常见的医院内感染致病菌之一，其耐药性使临床上铜绿假单胞菌的抗感染治疗更加棘手。多重耐药性铜绿假单胞菌(MDR-PA)耐药机制复杂多变，且常由多种耐药机制同时作用产生多重耐药性。中药抗耐药铜绿假单胞菌的应用有望延缓、抑制甚至逆转铜绿假单胞菌的耐药性，中药能对MDR-PA耐药性产生的多个环节进行干预，本文综述了中药抗耐药铜绿假单胞菌机制的研究进展。这些研究发展为中药抗耐药铜绿假单胞菌的进一步研究提供了新的研究方法及思路。

    [关键词] 中药;铜绿假单胞菌;耐药;耐药机制

    [中图分类号] R285.5? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)01(c)-0040-04

    [Abstract] Pseudomonas aeruginosa has become one of the most common pathogens of nosocomial infection in clinic， and its drug resistance has made it more difficult to treat the infection of Pseudomonas aeruginosa. The drug resistance mechanism of multidrug resistant Pseudomonas aeruginosa (MDR-PA) is complex and changeable， and it often produces multiple drug resistance by simultaneous effects of multiple drug resistance mechanisms. Application of traditional Chinese medicine against drug-resistant Pseudomonas aeruginosa is expected to postpone， to inhibit or even reverse the drug resistance of Pseudomonas aeruginosa. Traditional Chinese medicine can intervene in multiple links in the production of drug resistance of MDR-PA. This article reviews the research progress on mechanism of traditional Chinese medicine against drug-resistant Pseudomonas aeruginosa. These studies provide new research methods and ideas for further study of traditional Chinese medicine against drug-resistant Pseudomonas aeruginosa. ......