刘成思 王卫星

    [摘要] 急性胰腺炎(AP)是临床常见疾病，多器官功能障碍综合征和全身炎症反应综合征是其继发病症，也是导致AP死亡率高的常见原因。AP会导致肠黏膜屏障损伤，从而造成细菌移位，繼而引发内毒素血症和胰腺组织的继发感染。AP继发的微循环障碍、炎症介质过度释放、缺血再灌注损伤和肠上皮细胞凋亡在肠黏膜屏障损伤中也起重要作用。临床研究AP肠黏膜屏障损伤具有重要意义。

    [关键词] 急性胰腺炎;肠道损伤;研究进展

    [中图分类号] R576? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)01(c)-0033-04

    [Abstract] Acute pancreatitis (AP) is a common clinical disease. Multiple organ dysfunction syndrome and systemic inflammatory response synthesis are its secondary diseases， which are also common causes of high AP mortality. AP can lead to intestinal mucosal barrier damage， resulting in bacterial translocation， which can lead to endotoxemia and secondary infection of pancreatic tissue. Microcirculation disturbance， excessive release of inflammatory mediators， ischemia-reperfusion injury and intestinal epithelial cell apoptosis secondary to AP also play an important role in intestinal mucosal barrier injury. Clinical study of AP intestinal mucosal barrier damage is of great significance.

    [Key words] Acute pancreatitis; Intestinal injury; Research progress

    急性胰腺炎(AP)是一种由多种病因导致胰酶在胰腺内被激活后引起胰腺组织自身消化、水肿、出血甚至坏死的炎性反应 ......