孙永欣 姚刚 于挺敏 满玉红

    [摘要] 紧张型头痛(TTH)是最常见的原发性头痛类型，目前对其仍缺少足够重视。外周致敏、颅周肌肉压痛及肌肉的异常活动、中枢神经系统疼痛调节机制异常、细胞因子及炎性介质的代谢紊乱等因素可能从不同方面参与了TTH的发病过程。电生理技术、神经影像技术及检验技术为TTH发病机制的研究提供了有效手段。本文对TTH可能的发病机制及相应研究进展进行简要概括，以期加深对此疾病的了解，为基础研究及临床诊疗提供参考。

    [关键词] 紧张型头痛;机制;外周致敏;中枢疼痛调节

    [中图分类号] R255? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)01(c)-0037-04

    [Abstract] Tension-type headache (TTH) is the most common type of primary headache， which is still lacking enough attention. Factors such as peripheral sensitization， craniocerebral muscle tenderness and abnormal muscle activity， abnormal regulation mechanism of central nervous system pain， cytokines and metabolic disorders of inflammatory mediators may participate in the pathogenesis of TTH from different aspects. Electrophysiological techniques， neuroimaging techniques and testing techniques provide an effective means for the study of the pathogenesis of TTH. This article briefly summarizes the possible pathogenesis of TTH and the corresponding research progress， in order to deepen the understanding of this disease， and provide reference for basic research and clinical diagnosis and treatment. ......