刘远识 徐细明 陈心 伍龙

    [摘要] 肿瘤低表达lnRNA(lncRNA-LET)定位于15号染色體长臂2区4带15q24.1，具有抑制肿瘤的发生、发展、转移和促进凋亡的作用，已经被证实其存在于多种肿瘤组织中，且其表达下调。目前研究认为lncRNA-LET通过竞争性结合微小RNA(miRNA)作为竞争性内源RNA(ceRNA)而发挥作用，并充当该组miRNA的“分子海绵”。lncRNA-LET是目前研究的热点，其有望成为一种新的肿瘤诊断和预后的标志物以及潜在的治疗靶点。本文综述了近年来lncRNA-LET在肿瘤中的作用的先关研究，以期为ncRNA-LET与肿瘤的进一步研究提供参考。

    [关键词] 长链非编码RNA;肿瘤低表达;竞争性内源RNA;肿瘤

    [中图分类号] R730.5? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)03(c)-0026-05

    [Abstract] Tumor low expression of lnRNA (lncRNA-LET) is located in 15q24.1 of 4 bands of 2 region of long arm of chromosome 15， which can inhibit the occurrence， development， metastasis and apoptosis of tumors. It has been proved that lncRNA-LET exists in various tumors and its expression is down-regulated. At present， it is believed that lncRNA-LET plays a role as a competing endogenous RNA (ceRNA) by competing with microRNAs (miRNAs)and acts as a "molecular sponge" of this group of miRNAs. LncRNA-LET is a hotspot of current research， which is expected to become a new marker for diagnosis and prognosis of tumors and a potential therapeutic target. This paper reviews the recent phase studies on the role of lncRNA-LET in tumors ......