姜彤伟 郝珍珠 王冰梅 郭慧文 朴星虎 程祺

    [摘要] 心肌会因相对或绝对缺血而引起其代谢功能障碍，严重时会导致功能或者结构损伤。一定条件下，恢复心肌血液再灌注是有效的治疗方法，但再灌注会对心肌造成新的损伤，即心肌缺血再灌注损伤(MIRI)，而如何治疗和预防MIRI就成为心血管疾病中的重大课题。本文将对既往文献进行相关总结，阐述MIRI相关机制及药物治疗的研究进展。

    [关键词] 心肌缺血;再灌注损伤;中西医;中药;机制;细胞凋亡;信号通路

    [中图分类号] R259? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)03(c)-0043-05

    [Abstract] Myocardium may have metabolic dysfunction due to relative or absolute ischemia， which may lead to functional or structural damage in severe cases. Under certain conditions， restoring myocardial blood reperfusion is an effective treatment， but reperfusion can cause new myocardial injury， namely myocardial ischemia reperfusion injury (MIRI). How to treat and prevent MIRI has become a major issue in cardiovascular diseases. This article will summarize the previous literature， and elaborate the related mechanism of MIRI and the progress of drug treatment.

    [Key words] Myocardial ischemia; Reperfusion injury; Chinese and Western medicine; Traditional Chinese medicine; Mechanism; Apoptosis; Signaling pathway ......