陈师林 王兰 邓亚萍

    [摘要] 脓毒症是一组高发病率、高死亡率的临床综合征，早期识别和诊断是改善其预后的关键。生物标志物有助于客观评价病理生理过程、诊断疾病、监测疗效和评估预后。为了更好地指导临床诊治，寻求新的生物标志物是非常必要的。近年来已有许多学者就脓毒症生物标志物方面做了很多工作，大部分研究都集中在对吞噬细胞膜上表达的分子、细胞因子及急性期蛋白等的研究，本文即对相关生物标志物的近期研究展开论述。

    [关键词] 脓毒症；生物标志物；综述

    [中图分类号] R631 [文献标识码] A [文章编号] 1673-7210(2019)04(a)-0052-04

    Research progress of biomarkers for early identification and prognosis evaluation in sepsis

    CHEN Shilin1 WANG Lan2 DENG Yaping2

    1.Department of Pneumology，Dongzhimen Hospital， Beijing University of Chinese Medicine， Beijing 100700， China； 2.Department of Emergency， Dongzhimen Hospital， Beijing University of Chinese Medicine， Beijing 100700， China

    [Abstract] Sepsis is a group of clinical syndromes with high incidence and high mortality. Early recognition and diagnosis is the key to improve its prognosis. Biomarkers can evaluate the physiopathologic mechanism objectively， contribute to diagnose disease， monitor curative effect and predict prognosis. In order to better guide clinical diagnosis and treatment， it is necessary to seek new biomarkers. In recent years， many scholars have done a lot of work on sepsis biomarkers. Most of the researches focus on the molecules expressed on the phagocytic cell membrane ......