徐志 刘毅 邹刚

    [摘要] 运动系统损伤包括肌腱、韧带、软骨等软组织损伤，是我国青壮年常见病。因原组织再生能力较弱，瘢痕形成及局部炎症演变，增加了后期创伤型关节炎的风险。目前针对运动系统损伤治疗采用生长因子干预较为热门，TSG-6被发现可调节损伤信号的反应而减少炎症，防止纤维血管组织的形成，改善了愈合肌腱-骨界面的结构和附着强度，具有促进软骨形成和腱-骨愈合作用。本文就TSG-6抑制瘢痕形成、促进腱-骨愈合、保护软骨方面的研究作一综述。

    [关键词] TSG-6；腱-骨愈合；软骨修复；肌腱损伤；干细胞移植

    [中图分类号] R619.6 [文献标识码] A [文章编号] 1673-7210(2019)04(a)-0056-04

    [Abstract] Locomotor system injuries includes the injuries of tendons， ligaments， cartilage and other soft tissue injuries， which is a common disease in young adults in China. Because the original tissue regeneration ability is weak， scar formation and local inflammation evolution increase the risk of later traumatic arthritis. The ability of the original tissue regeneration is weak， leading to scar formation and local inflammation evolution， which increase the risk of later traumatic arthritis. At present， the use of growth factor intervention for the treatment of locomotor system injury is more popular. TSG-6 was found to regulate the response of injury signals to reduce inflammation， prevent the formation of fibrous vascular tissue， improve the structure and adhesion strength of the healing tendon-bone interface ......