刘雅雯 张尤历 徐岷

    [摘要] 核内不均一核糖核蛋白(hnRNPs)是一类RNA结合蛋白，主要參与RNA剪切、mRNA的加工、端粒合成、DNA修复、基因表达调控及蛋白质翻译等复杂多样的生物进程。hnRNPA2/B1属于该蛋白家族中的成员之一，其在人体大多数组织中表达且具有多种功能。研究发现hnRNPA2/B1在多种恶性肿瘤中均存在差异性表达，并且可参与调控基因的表达、促进增殖与迁移能力、抑制凋亡及调控肿瘤耐药，在恶性肿瘤的诊断、治疗以及预后判断等方面都具有重要的临床价值。本文就hnRNPA2/B1在肺癌、乳腺癌、胰腺癌及肝癌等多种恶性肿瘤中的研究进展作一综述。

    [关键词] 核内不均一核糖核蛋白；hnRNPA2/B1；恶性肿瘤

    [中图分类号] R730 [文献标识码] A [文章编号] 1673-7210(2019)04(c)-0023-04

    [Abstract] Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of RNA-binding proteins that play a key role in complex and various biological processes such as RNA splicing， mRNA processing， telomere synthesis， modulation of gene expression， translation of mRNAs. Heteregeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) is a member of this proteins family. hnRNPA2/B1 abundantly and ubiquitously expresses in most human tissues and has various functions. Researches indicate that hnRNPA2/B1 is abnormally expressed in diverse malignant tumors， and it can modulate the expression of genes， promote the abilities of proliferation and migration， inhibit apoptosis and regulate tumor resistance in tumors. It also shows that hnRNPA2/B1 has important clinical value in the diagnosis ......