廖丹 钱波 徐敏

    [摘要] FoxO1作为叉头转录因子家族中的成员，能够促进肝细胞糖异生基因的表达，同时促进ApoC-Ⅲ的表达，形成非酒精性脂肪肝病导致肝纤维化；FoxO1通过调节自噬基因的表达及参与肝星状细胞自噬来调节肝纤维化；FoxO1能通过参与肝星状细胞细胞周期阻滞而调节肝纤维化；PDGF因子可以通过调节FoxO1表达参与肝星状细胞的活化而调节肝纤维化；FoxO1通过参与脂肪细胞、肌纤维细胞的分化来调节肝纤维化的形成。本文将从上述方面阐述FoxO1与肝纤维化的关系进行综述。

    [关键词] FoxO1；肝纤维化；肝星状细胞；糖脂代谢；自噬；细胞周期阻滞；细胞分化

    [中图分类号] R575.2 [文献标识码] A [文章编号] 1673-7210(2019)05(a)-0054-04

    Advances in the relationship between FoxO1 transcription factors and liver fibrosis

    LIAO Dan1 QIAN Bo2 XU Min1

    1.Department of Gastroenterology， Shanghai First People′s Hospital， Nanjing Medical University， Shanghai 200080， China； 2.Department of Internal Medicine， Maternal and Child Health Hospital of Jiangsu Province， Jiangsu Province， Qidong 226200， China

    [Abstract] FoxO1， as a member of the forkhead transcription factor family， can promote the expression of gluconeogenesis genes in hepatocytes， and promote the expression of ApoC-Ⅲ to form liver fibrosis caused by nonalcoholic fatty liver disease； FoxO1 regulates the expression of autophagy genes. Participate in autophagy of hepatic stellate cells to regulate liver fibrosis； FoxO1 can participate in hepatic stellate cell cycle arrest to regulate liver fibrosis； PDGF factor can regulate FoxO1 expression involved in hepatic stellate cell activation and regulate liver fibrosis； FoxO1 participates in fat differentiation of cells and myofibroblasts regulates the formation of liver fibrosis. This article will review the relationship between FoxO1 and liver fibrosis in the above aspects. ......