张雯雯 刘可可 刘璐瑶 曹娟 李波 董春玲

    [摘要] 口腔鳞状细胞癌(OSCC)是世界排名第六的恶性肿瘤，5年生存率不足50%，其发病机制目前尚未完全阐明。肿瘤相关成纤维细胞(CAFs)作为肿瘤微环境中的重要细胞成分之一，在肿瘤的侵袭、转移及血管生成中发挥重要的作用。CAFs主要通过分泌生长因子、修饰细胞外基质、支持血管生成以及抑制抗肿瘤免疫应答来促进肿瘤的发生发展。以CAFs作为治疗靶点，可以有效地抑制OSCC的侵袭和转移，限制肿瘤血管生成，进而为OSCC的干预提供新的治疗策略。本文就CAFs在OSCC的作用及其靶向治疗的研究进展进行综合论述。

    [关键词] 肿瘤相关成纤维细胞;口腔鳞状细胞癌;侵袭;转移;治疗

    [中图分类号] R739.8 ? ? ? ? ?[文献标识码] A ? ? ? ? ?[文章编号] 1673-7210(2019)05(b)-0029-04

    [Abstract] Oral squamous cell carcinoma (OSCC) is the sixth most common malignant tumor in the world with a five-year survival rate of less than 50%. Its pathogenesis has not been fully elucidated. Cancer-associated fibroblasts (CAFs)， as one of the important cellular components in the tumor microenvironment， play an important role in tumor invasion， metastasis and angiogenesis. CAFs promote tumor development mainly by releasing growth factors， modifying extracellular matrix， supporting angiogenesis， and inhibiting anti-tumor immune responses. CAFs-targeted therapy may effectively inhibit the invasion and metastasis of OSCC， and limit tumor angiogenesis， which provides new strategies for the treatment of OSCC. This article comprehensively discusses the advance research on the role of CAFs in OSCC and its targeted therapy. ......