段朝阳 林燕 高洁 韩锦 马晓桃 卢家美 吕治安 王莉

    [摘要] 目的 研究血清成纖维细胞生长因子23(FGF23)、胎球蛋白A(FA)水平与维持性血液透析患者冠状动脉钙化的关系。 方法 选择2016年4月～2017年4月西安交通大学第二附属医院收治的维持性血液透析患者97例，所有患者行冠状动脉多层螺旋CT检查，并根据冠状动脉Agaston评分(CACs)将患者分为无钙化组(CACs 0.05)。无钙化组、轻度钙化组、中度钙化组、重度钙化组血磷、血清FGF23水平呈逐渐升高趋势，而血清FA水平呈逐渐降低趋势，各组间比较差异均有统计学意义(均P 0.05)。经Pearson相关性分析可得：维持性血液透析患者冠状动脉钙化程度与年龄、透析时间、血磷、血清FGF23水平均呈正相关，而与血清FA水平呈负相关(均P 400 points) 19 cases. Basic data and biochemical indexes of the patients in each group were compared， and correlation analysis was conducted. Results The age of patients in the severe calcification group was significantly higher than that in the non-calcification group， the mild calcification group and the moderate calcification group， and the duration of dialysis was longer than that in the non-calcification group， the mild calcification group and the moderate calcification group， and the duration of dialysis in the moderate calcification group was longer than that in the non-calcification group， with statistically significant differences (all P 0.05). The levels of serum phosphorus and FGF23 in the non-calcification group ......