田成 袁岸龙

    [摘要] 微生物群由共生细菌和其他宿主上皮屏障中存在的微生物组成。微生物群从局部维持稳态到系统地调节机体代谢、造血、炎症、免疫等生理功能都有着重要作用。微生物群还参与上皮屏障和无菌组织中癌症的发生、发展和传播。胃肠道微生物不仅参与了癌症的发生，而且参与了癌症预防和化疗的效果。现就胃肠道微生态与肿瘤及其药物化疗的相关研究作一综述。

    [关键词] 微生物群;胃癌;结肠癌;化疗;效果

    [中图分类号] R573.6? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)06(a)-0037-05

    Research progress of gastrointestinal flora and tumor chemotherapy drugs

    TIAN Cheng1? ?YUAN Anlong2

    1.School of Medicine， Wuhan University of Science and Technology， Hubei Province， Wuhan? ?430065， China; 2.Department of Gastroenterology， Xiaogan Hospital Affiliated to Wuhan University of Science and Technology， Hubei Province， Xiaogan? ?432000， China

    [Abstract] The microbiome consists of symbiotic bacteria and other microorganisms present in host epithelial barriers. Microflora plays an important role in maintaining local homeostasis and systematically regulating physiological functions such as metabolism， hematopoiesis， inflammation and immunity. Microbiota are also involved in the occurrence， development and spread of cancer in epithelial barriers and sterile tissues. Gastrointestinal microbes are involved not only in cancer ......