戴助 祝红达

    [摘要] 由于眼睛独特的生理结构，常规眼局部给药用于眼后段疾病的治疗一直是困扰医药工作者的一大难题。基于纳米递送策略研发的眼部给药系统因具有尺寸小、渗透性强、对生物膜表面黏附性强等特点，有望发展成为安全、有效、经济和无创的新型眼部药物输送系统，特别在眼后段给药中越来越受到重视。本文重点介绍非侵入性眼后段给药的各类纳米药物递送策略，包括纳米粒、脂质体、纳米胶束、纳米悬浮液和纳米乳等给药系统。

    [关键词] 非侵入性;眼后段;纳米技术;给药系统

    [中图分类号] R944? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)06(a)-0046-04

    Reseach progress on nano-drug delivery strategy of non-invasive drug administration of the posterior eye segment

    DAI Zhu1，2? ?ZHU Hongda1

    1.College of Bioengineering and Food Sciences， Hubei University of Technology， Hubei Province， Wuhan? ?430068， China; 2.Pharmacy Department， Hubei Cancer Hospital， Hubei Province， Wuhan? ?430079， China

    [Abstract] Because of the unique physiological structure of eyes， routine eye topical administration for the treatment of posterior eye disease has always been a difficult problem for medical workers. The developed drug delivery system of eyes based on nano-drug delivery strategy has characters of small size， strong penetration， strong surface adhesion for biofilm， and so on， which is expected to develop into a safe ......