张莉 邱艳

    [摘要] 隐匿性乙型肝炎病毒感染(OBI)指用高灵敏度的核酸检测可在HBsAg阴性感染者肝组织中检测到HBV DNA。本文介绍了OBI形成的基因分子机制：s、p、x和c基因的开放阅读框突变、起始密码子和终止密码子突变;基因调控序列突变影响转录过程及转录后调控;表观遗传调控。目前OBI个体HBV复制、基因表达过程中的表观遗传调控研究尚处于起步阶段，研究前景广阔。此外，本文对欧洲、南非、东南亚以及中国献血者OBI形成的基因分子生物学机制进行了梳理和汇总。

    [关键词] 隐匿性乙型肝炎病毒感染;乙肝表面抗原;乙肝表面抗体;基因分子机制;表观遗传调控;献血者

    [中图分类号] R575.1? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)06(b)-0023-05

    Advance of molecular mechanism of occult hepatitis B virus

    ZHANG Li? ?QIU Yan

    Beijing Red Cross Blood Center， Beijing? ?100088， China

    [Abstract] Occult hepatitis B virus infection (OBI) means that HBV DNA can be detected in liver tissues of HBsAg negative infected people with highly sensitive nucleic acid detection. This paper introduces the gene molecular mechanism of OBI formation： open reading frame mutation， initiation codon and termination codon mutations of s， p， x and c genes; effect of mutations of gene regulatory sequences on transcriptional processes and post-transcriptional regulation; epigenetic regulation. At present ......