彭拥军 乔玉 李忠仁 傅淑平 储继红 姜鹏君 朱冰梅

    [摘要] 细胞自噬与脑缺血联系密切，两者相互影响，相互作用，脑缺血可激发细胞自噬作用，同时细胞自噬可加重或减轻脑缺血后神经细胞的损伤。脑缺血可导致细胞自噬的发生，细胞自噬适度激活，有利于脑缺血后神经细胞的修复，但是细胞自噬激活过度或不足，又可导致细胞凋亡，加重脑损伤。因此，细胞自噬激活的度需要一定的控制和把握，同时需要进一步的研究自噬对脑缺血作用的具体信号通路及干预信号通路具体手段等问题。本文探讨近年来国内外关于细胞自噬与脑缺血之间的关系进展，为其临床研究提供新思路。

    [关键词] 自噬;脑缺血;信号通路;综述

    [中图分类号] R743? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)08(a)-0046-04

    [Abstract] Autophagy is closely related to cerebral ischemia， and the two interact with each other. Cerebral ischemia can stimulate autophagy， and meanwhile， autophagy can aggravate or reduce the damage of nerve cells after cerebral ischemia. Cerebral ischemia can lead to cell autophagy and cell autophagy activation moderately， conducive to the repair of nerve cell after cerebral ischemia， but excessive or insufficient cell autophagy activation， and can lead to cell apoptosis， increase brain damage， so the cell autophagy activation takes control and grasp the degrees， also need further to study the roles of autophagy in cerebral ischemia specific signal and interference signal pathways in concrete means and so on. This article explores the relationship between autophagy and cerebral ischemia at home and abroad in recent years ......