邢烨 袁娜 韩睿

    [摘要] 糖尿病溃疡是糖尿病最严重的并发症之一，但目前缺乏有效治疗手段，且治疗费用高昂。MicroRNAs(miRNAs)在糖尿病溃疡的愈合过程中发挥重要作用，通过调控靶基因的表达，对生长因子和细胞因子、信号通路等进行调节，从而影响止血、抗炎、增殖和重塑等溃疡愈合的各个阶段，本文分别就miRNAs对糖尿病溃疡愈合的促进和抑制作用的研究现状进行综述，旨在为糖尿病溃疡的治疗及疗效评判方面提供新的思路。

    [关键词] 糖尿病;溃疡;创面愈合;微小RNAs;

    [中图分类号] R587? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)08(a)-0058-04

    [Abstract] Diabetic ulcer is one of the most serious complications of diabetes mellitus， but there is a lack of effective treatment and the cost of treatment is high. MicroRNAs (miRNAs) plays an important role in the healing process of diabetic ulcer. Through regulating the expression of target genes， regulating growth factors， cytokines， signal pathways and so on， thus affecting hemostasis and anti-inflammation. In this paper， the promotion and inhibition of miRNAs on diabetic ulcer healing are reviewed in order to provide new ideas for the treatment and curative effect evaluation of diabetic ulcer.

    [Key words] Diabetes mellitus; Ulcer; Wound healing; MicroRNAs

    随着人口老龄化加速和生活水平提高，糖尿病发病率迅速上升，已成为一个流行病。糖尿病患者伤口愈合能力严重受损，这些损伤进一步发展为糖尿病溃疡，往往导致住院率、截肢率、致死率增加 ......