王安琪 刘云鹏 卢文卿 郑春雷 车晓芳

    [摘要] 前胶原-赖氨酸、2-酮戊二酸5-双加氧酶(PLOD)家族包含PLOD1、PLOD2和PLOD3三个成员，分别编码赖氨酸羟化酶1(LH1)、LH2和LH3，主要作用是通过催化前胶原分子翻译后的赖氨酸残基羟化促进胶原的成熟和分泌。PLOD家族蛋白表达主要受低氧诱导因子-1α、转化生长因子-β1等因子调控，不仅参与胶原成熟和细胞外基质重塑，还能诱导上皮-间质转化，在肿瘤发生发展中发挥重要作用。本文拟就PLOD的结构特点、调控因素、功能及在肿瘤进展中的作用进行综述。

    [关键词] 赖氨酸羟化酶;胶原;肿瘤;转移

    [中图分类号] R730.5? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)08(c)-0029-04

    [Abstract] The procollagen-lysine， 2-oxoglutarate 5-dioxygenase (PLOD) family includes three members， PLOD1， PLOD2 and PLOD3， and encodes lysine hydroxylase 1 (LH1)， LH2 and LH3， respectively. The main role of PLOD is to promote collagen maturation and secretion by catalyzing the hydroxylation on lysine residues of procollagen. The expression of PLODs is mainly regulated by HIF-1， TGFβ-1 and so on. PLODs not only can promote collagen maturation and extracellular matrix remodeling， but also can induce epithelial mesenchymal transformation and can play vital role in tumorigenesis and development. This paper reviews the structural features， regulatory factors， functions of PLOD and its role in tumor progression. ......