刘严慈 孙鹏慧 卢朝阳 惠吴函

    [摘要] 经典Ph染色体阴性的骨髓增殖性肿瘤(MPN)是造血干细胞克隆性疾病。血栓是影响MPN患者生存的最主要并发症。MPN血栓形成机制可能与以下多种机制相关，包括血细胞数量增多及活化、内皮细胞异常、凝血系统激活、微颗粒与炎性细胞因子增多、JAK2V617F基因突变等。本文对MPN并发血栓形成机制的研究进展进行了综述，阐明这些机制有助于临床寻找新的预测血栓的生物学标志，为MPN患者血栓预防和治疗提供参考。

    [关键词] 血栓形成;骨髓增殖性肿瘤;细胞活化;基因突变

    [中图分类号] R733.3? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)08(c)-0032-04

    [Abstract] Classic negative Ph chromosome of myeloproliferative neoplasms (MPN) is a clonal disease of hematopoietic stem cells. Thrombus is the most important complication that affects the survival of MPN patients. The mechanism of thrombosis of MPN may be related to a variety of mechanisms including increased blood cell counts and activation， abnormal endothelial cells， activation of the blood coagulation system， increased microparticles and inflammatory cytokines， and JAK2V617F gene mutation. This paper reviews the research progress of MPN complicated thrombosis mechanism， elucidates that these mechanisms are helpful for clinical search new biological markers to predict thrombosis， so as to provide reference for thrombus prevention and treatment in MPN patients. ......