喻珮 刘璐 李志娟 付渊博 袁芳 李彬

    [摘要] 参照《實验动物国家标准》将膝骨关节炎模型分为小型动物模型、大中型动物模型及灵长类动物模型，并将国内外常用动物模型依据自发性模型、诱发性模型进行归类。自发性模型包括天然自发模型、转基因模型，诱发性模型分为饮食诱发、药物注射诱发、手术诱发、制动诱发及寒冷诱发。不同模型的选择以及造模方法的应用，各自适用于不同的研究目的。

    [关键词] 膝骨关节炎;动物模型;造模方法;研究进展

    [中图分类号] R-332? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)09(c)-0041-04

    Research progress of experimental animal models of knee osteoarthritis

    YU Pei1，2? ?LIU Lu1? ?LI Zhijuan1，2? ?FU Yuanbo1? ?YUAN Fang1? ?LI Bin1

    1.Department of Acupuncture and Moxibustion， Beijing Hospital of Traditional Chinese Medicine， Capital Medical University? Beijing Key Laboratory of Acupuncture Neuromodulation， Beijing? ?100010， China; 2.Graduate School， Beijing University of Chinese Medicine， Beijing? ?100029， China

    [Abstract] According to National Standard for Laboratory Animals， knee osteoarthritis models are divided into small animal models， large and medium animal models and primate animal models. The commonly used animal models at home and abroad are classified according to spontaneous model and induced model. Spontaneous model includes natural spontaneous model and genetically modified model ......