马梦青 曹长春 万辛

    [摘要] 随着医学影像学和介入诊疗技术的发展，造影剂的使用越来越广泛，由此导致的造影剂肾病的发病率和死亡率也逐渐升高，已经成为医源性急性肾损伤的第三大原因。造影剂肾病目前尚无有效的治疗措施，因此预防极为重要。目前，主要的预防措施包括识别造影剂肾病的高危人群、造影剂的选择、远端缺血预处理，相关药物预防如水化疗法、碱化疗法、抗氧化剂、血管扩张剂等，但多数预防措施仍存在争议，还有待进一步研究探讨。本文将重点讨论造影剂肾病的预防措施。

    [关键词] 造影剂肾病;造影剂;药物预防;远端缺血预处理

    [中图分类号] R692? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)09(c)-0049-04

    Reserch advances in the prevention of contrast nephropathy

    MA Mengqing1? ?CAO Changchun1? ?WAN Xin2

    1.Department of Nephrology， Sir Run Run Hospital， Nanjing Medical University， Jiangsu Province， Nanjing? ?211166， China; 2.Department of Nephrology， Nanjing First Hospital， Nanjing Medical University， Jiangsu Province， Nanjing? ?210006， China

    [Abstract] With the development of medical imaging and interventional diagnosis and treatment technology， the use of contrast agent is more and more extensive. The resulting incidence and mortality of contrast nephropathy are also increasing. It has become the third major cause of iatrogenic acute kidney injury. There is no effective treatment for contrast nephropathy， so prevention is very important. Currently ......