自噬在类风湿关节炎发病机制中的作用进展
秦倩 青玉凤 周闻君 王聃 熊琴 杨小红[摘要] 类风湿关节炎是一种慢性、炎性自身免疫性疾病,其发病机制尚未完全明确。自噬广泛存在于真核生物中,是维持细胞内正常生理活动及稳态的一种代谢过程,其异常与多种疾病发生、发展相关,近年来受到广泛关注成为研究热点之一。自噬可通过多种途径影响类风湿关节炎的发生、发展,本文就此进行综述。
[关键词] 类风湿关节炎;自噬;发病机制;综述
[中图分类号] R593.22 ? ? ? ? ?[文献标识码] A ? ? ? ? ?[文章编号] 1673-7210(2019)10(a)-0059-04
Progress in the role of autophagy in the pathogenesis of rheumatoid arthritis
QIN Qian1 ? QING Yufeng2 ? ZHOU Wenjun2 ? WANG Dan2 ? XIONG Qin3 ? YANG Xiaohong1,4
1.Department of Microbiology and Immunology, College of Basic Medical Sciences, North Sichuan Medical College, Sichuan Province, Nanchong ? 637000, China; 2.Department of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College, Sichuan Province, Nanchong ? 637000, China; 3.Department of Geriatrics, Affiliated Hospital of North Sichuan Medical College, Sichuan Province, Nanchong ? 637000, China; 4.Party Committee Office, the Second Affiliated Hospital of North Sichuan Medical College, Sichuan Province, Nanchong ? 637000, China
[Abstract] Rheumatoid arthritis is a chronic, inflammatory autoimmune disease ......
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