毛文姣 张红梅

    [摘要] 肠道微生物群的改变被认为肠易激综合征(IBS)发病机制的病因。肠道菌群-免疫失调导致肠道微环境的改变，诱发肠道的低度炎症。肠道碱性磷酸酶(IAP)通常能保护宿主免受肠道炎症和主要在结肠内的组织损伤，是维持肠道内环境稳定所必需的重要黏膜防御因子，被认为是肠道微生物群组成的潜在调节器。基于此，IAP相关通路可能是阐明针刺对肠道菌群-免疫稳定作用分子生物学机制的新切入点，促进对从脾论治与调控肠道菌群关系的认识，丰富中医从脾论治的科学内涵。

    [关键词] 肠易激综合征;肠道微生物;肠道碱性磷酸酶;肠道菌群-免疫失调

    [中图分类号] R246.1 ? ? ? ? ?[文献标识码] A ? ? ? ? ?[文章编号] 1673-7210(2019)10(a)-0126-04

    Based on intestinal alkaline phosphatase signaling pathway to discuss the mechanism of acupuncture maintaining intestinal flora-immune stability

    MAO Wenjiao1 ? ZHANG Hongmei2

    1.Department of Acupuncture， the Second Hospital of Nanjing， Jiangsu Province， Nanjing ? 210003， China; 2.Department of Clinical Testing Center， the Second Hospital of Nanjing， Jiangsu Province， Nanjing ? 210003， China

    [Abstract] The alteration of intestinal microflora is considered to be the cause of the pathogenesis of Irritable bowel syndrome (IBS). Intestinal flora-immune disorders lead to changes in the intestinal microenvironment， which induce low-grade inflammation of the intestines. Intestinal alkaline phosphatase (IAP) considered as a potential regulator of intestinal microflora ......