高满满 颜丙春

    [摘要] 缺血性脑卒中后认知功能障碍是脑卒中后残疾的重要组成部分，不仅增加患者病死率，亦严重影响患者的日常生活能力和社会功能。目前大量的生物标志物，如酶学、血清、脑脊液、炎性介质、激素、基因型、RNA谱已经被证实对缺血性脑卒中后认知功能障碍有预测作用，另外，神经影像学检查、脑血管病及其危险因素如血压、血糖、肾功能等异常指标均与认知功能障碍有相关性，本文就已知的生物学标志物及预测因子进行综述，以期为缺血性脑卒中后认知功能障碍的预测和诊断提供依据。

    [关键词] 酶学;血清学;基因学;影像学;血管疾病

    [中图分类号] R743.3? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)01(c)-0026-05

    Research progress in biomarkers and predictors of cognitive impairment after ischemic stroke

    GAO Manman? ?YAN Bingchun

    Medical College， Yangzhou University， Jiangsu Province， Yangzhou? ?225009， China

    [Abstract] Cognitive impairment after ischemic stroke is an important part of post-stroke disability， which not only increases the mortality rate of patients， but also seriously affects patients′ daily living ability and social function. A large number of biomarkers such as enzymes， serum， cerebrospinal fluid， inflammatory mediators， hormones， genotypes and RNA profiles have been shown to predict cognitive impairment after ischemic stroke. In addition， neuroimaging， cerebrovascular disease and its risk factors such as blood pressure ......